does bladder cancer metastasis to bone



It’s not uncommon for bladder cancer to metastasize to the lungs, liver or bones. This can cause pain and other symptoms in distant parts of the body. In many cases, metastatic bladder cancer also causes general complications such as fatigue and weight loss.

How dangerous is bladder cancer?

Urothelial carcinoma of the bladder metastatic to bone marrow presenting as isolated thrombocytopenia The skeletal system is a frequent site for metastases of urothelial carcinoma (UC) of the bladder (22-37%). Of those cases involving bone, …

Which cancers mostly are associated with bone metastasis?

However, the most common sites for distant bladder cancer metastases include the: Lungs; Bones; Liver; Metastatic bladder cancer can also spread to other organs in the urinary and reproductive tracts, such as the prostate, uterus and vagina. How is metastatic bladder cancer treated? The way that metastatic bladder cancer is treated depends primarily on where the …

What are the symptoms of end stage bladder cancer?

Bladder. What are bone metastases? Bone metastases are not the same as cancer that starts in the bone. Cancer that starts in the bone is called primary bone cancer. There are different types of primary bone cancers, like osteosarcoma and Ewing sarcoma. A tumor that has metastasized to bone is not made of bone cells.

What is the recovery time for bladder cancer surgery?

 · When cancer cells spread, it’s called metastasis. Cancer is always named for the place where it starts. So when bladder cancer spreads to the bone (or any other place), it’s still called bladder cancer. It’s not called bone cancer unless it starts in the bone. The bladder The bladder is a hollow organ that stores urine before it leaves your body.


Can bladder cancer spread to the bone?

Bladder cancer that spreads to the bones is called secondary bone cancer. You might have different treatments to help strengthen your bones and prevent problems.

Where does bladder cancer typically metastasize?

CONCLUSION. Lymph nodes, bones, lung, liver, and peritoneum are the most common sites of metastasis from bladder cancer. Tumors in a more advanced T category and those with atypical histologic features metastasize earlier. Tumors with atypical histologic features also have a higher frequency of peritoneal metastasis.

When bladder cancer goes to the bones?

Bone is an unrecognized, relatively common site of metastasis of from urothelial carcinoma. Reports estimate the frequency of bone metastases range from 25-47%. [18] However, only 5-15% of patients with urothelial cancer will have bone as the only site of metastatic disease.

What are the symptoms of metastatic bladder cancer?

Symptoms of metastatic bladder cancerBlood in the urine.Frequent urination.Pain or burning during urination.Need to urinate despite an empty bladder.Being unable to urinate.Lower back and abdominal pain.Swelling in the feet.Fatigue and weakness.More items…•

How fast does bladder cancer metastasize?

As many as 50% of patients with muscle-invasive bladder cancer may have occult metastases that become clinically apparent within 5 years of initial diagnosis and around 5% will have distant metastasis at the time of initial diagnosis. Most patients with overt metastatic disease die within 2 years despite chemotherapy.

Can bladder cancer spread to legs?

Though bone metastases have been observed with bladder cancer, they are considerably less common when compared to prostate and breast cancer. Common bone metastases sites for bladder carcinoma include pelvis and spine [2]. Our case reports an unusual metastasis to the tibia.

How long can you live when cancer spreads to bones?

Most patients with metastatic bone disease survive for 6-48 months. In general, patients with breast and prostate carcinoma live longer than those with lung carcinoma.

How long can you live with metastatic bladder cancer?

Patients who present with metastatic bladder cancer generally have a poor prognosis, surviving only very few months (1). However, some patients may live considerably longer. If a patient is able to withstand palliative chemotherapy, their remaining lifetime may be extended with systemic treatments.

Does bladder cancer usually spread?

Bladder cancer often spreads locally or to lymph nodes before spreading distantly, though this is not always the case. The lungs and bones are the most common areas for metastases to develop. When bladder cancer spreads to another area, it is still bladder cancer.

Does bladder cancer spread quickly?

They tend to grow and spread slowly. High-grade bladder cancers look less like normal bladder cells. These cancers are more likely to grow and spread.

When does bladder cancer spread to the lungs?

It’s not uncommon for bladder cancer to metastasize to the lungs, liver or bones. This can cause pain and other symptoms in distant parts of the body. In many cases, metastatic bladder cancer also causes general complications such as fatigue and weight loss.

How long can you live with metastatic bladder cancer?

Patients who present with metastatic bladder cancer generally have a poor prognosis, surviving only very few months (1). However, some patients may live considerably longer. If a patient is able to withstand palliative chemotherapy, their remaining lifetime may be extended with systemic treatments.

How Does The Doctor Know I Have Bladder Cancer?

Bladder cancer might cause symptoms such as: 1. Having trouble peeing 2. Feeling pain when peeing 3. Needing to go more often than normal 4. Seeing…

Tests to Look For Bladder Cancer

Your doctor may do other tests to find out more about the cancer. Some of them are:X-ray: Dye is put into a vein for a special x-ray of the kidneys…

How Serious Is My Cancer?

If you have bladder cancer, the doctor will want to find out how far it has spread. This is called staging. Your doctor will want to find out the s…

What Kind of Treatment Will I Need?

There’s more than one way to treat bladder cancer. You might want to get a second opinion about the best treatment plan for you. Doctors may have d…

What Will Happen After Treatment?

You will be glad when treatment is over. But it’s hard not to worry about cancer coming back. Even when cancer never comes back, people still worry…


How does bladder cancer spread?

Bladder cancer spreads when cancerous cells reproduce and invade surrounding healthy tissues. This is known as metastasis. Usually, metastatic bladder cancer refers to cancer that has spread to distant organs, but metastasis can occur locally in the muscles and connective tissues that are directly adjacent to the bladder as well.

What is the treatment for bladder cancer?

Potential treatment options may include chemotherapy, radiation therapy and clinical trials.

Can bladder cancer be metastasized to lymphatic system?

Once cancerous cells have reached the lymphatic system, they can make their way to almost any part of the body. However, the most common sites for distant bladder cancer metastases include the:

Can bladder cancer spread to other organs?

Metastatic bladder cancer can also spread to other organs in the urinary and reproductive tracts, such as the prostate, uterus and vagina.

Does Moffitt Cancer Center treat bladder cancer?

At Moffitt Cancer Center, we’ve treated many patients with metastatic bladder cancer, creating ta ilored treatment plans for every single one. To help ease the burdens of treatment, we also offer comprehensive supportive care services for patients and their caregivers.

What is the term for a tumor that forms in the bone?

The new tumor that forms is called the secondary tumor. Secondary tumors in the bone are called bone metastases. Different types of cancer tend to spread to certain parts of the body. These cancers commonly spread to the bones: Breast. Kidney.

What is it called when a tumor spreads to the bone?

Cancer that has started in one place can spread to and invade other parts of the body. This spread is called metastasis. If a tumor spreads to the bone, it’s called bone metastasis. Cancer cells that have spread to the bone can damage the bone and cause symptoms. Different treatments can be used to control the symptoms and the spread …

What is the term for a tumor that breaks away from the body?

When cells break away from a cancer tumor, they can move through the bloodstream or lymph vessels to other parts of the body. Cancer cells can settle in an organ far from where it started and start a new tumor. The original tumor that cells break away from is called the primary tumor. The new tumor that forms is called the secondary tumor. Secondary tumors in the bone are called bone metastases.

How do you know if you have metastasis?

If bone metastasis affects your bone marrow, you may have other symptoms that are caused by lower blood cell counts. Your red blood cell levels may drop, causing anemia. Signs of anemia are tiredness, weakness, and shortness of breath. If white blood cells are affected, you may get infections. Signs of infection include fevers, chills, fatigue, or pain. If your platelets are low, you may bruise or bleed very easily.

How does a bone scan work?

In a bone scan, a mildly radioactive tracer is put into your blood through a vein. The tracer is attracted to diseased bone cells all over your body. This helps diseased bone show up more clearly on the scan.

How to find cancer cells?

PET scan. This imaging test uses a type of sugar that’s radioactive. This sugar is put into your blood. Cancer cells absorb large amounts of the sugar, compared to normal cells. After the injection, you lie on a table in a PET scanner, while your whole body is imaged. A special camera takes pictures of the radioactive areas found in your body. A PET scan is not very detailed, but can sometimes find tumors too small to be seen on other tests. If an abnormal area is seen, your doctor will likely order another test for more information. This may be a CT scan or MRI. New machines combine PET and CT scans for more detailed images all at once.

What is the outer layer of bone called?

The outer layer of bone is called the cortex. The spongy center of bone is called bone marrow. Bone is alive and always repairing and renewing itself in a process called remodeling. Two kinds of cells help with this: Osteoblasts are cells that build new bone.

How do you know if you have bladder cancer?

Signs of bladder cancer are problems peeing, pain when peeing, needing to go more often than normal, and seeing blood in your urine

What is the best test to find out if you have bladder cancer?

Ultrasound: This test uses sound waves to make pictures of the organs inside your body, like your bladder and kidneys. It can help show the size of a bladder cancer and if it has spread. Bone scan: A bone scan can help show if bladder cancer has spread to the bones. This test is not done unless you have bone pain.

What tests are done to check for bladder cancer?

This might include a rectal exam, during which a gloved finger is put into your rectum. If you are a woman, a pelvic exam might also be done.

What is it called when cancer cells spread to other parts of the body?

For instance, cancer cells in the bladder can travel to the bone and grow there. When cancer cells spread, it’s called metastasis . Cancer is always named for the place where it starts.

Where is the bladder located?

The bladder is a hollow organ that stores urine before it leaves your body. It sits in the lowest part of your belly, called your pelvis. Urine is made in your kidneys. Tubes called ureters connect your kidneys to the bladder. Urine flows through the ureters and into your bladder, where it’s stored. When you urinate (pee), the bladder squeezes the urine out through a tube called the urethra.

Can a test show if bladder cancer is growing?

Tests can show how deeply the cancer has grown into the bladder wall.

Can bladder cancer be surgically removed?

Surgery is done for most bladder cancers. The type you have depends on the stage of the cancer.

How do you know if you have bladder cancer?

The most common symptom of bladder cancer is blood in the urine that is visible, which is experienced by around 80% to 90% of patients diagnosed. Around 20% to 30% of patients experience other symptoms related to urination, including. Needing to urinate more frequently than usual. Pain or burning before, during, or after urination.

What tests are done to find out if bladder cancer is spreading?

This may include imaging scans, such as MRI, CT/CAT scans, and/or x-rays. For patients with the symptom of bone pain, bone scans may be used to see if the cancer cells have spread …

What is bone pain?

October 2, 2017. Bone pain is a symptom that is experienced by some patients diagnosed with bladder cancer. 1,2 Bone pain is not usually caused by bladder cancer, but it can potentially be a symptom of bladder cancer that is at a more advanced stage. In most patients who are diagnosed, bladder cancer cells start to grow—and can gather together …

What is the procedure to examine the inside of the bladder?

A procedure called cystoscopy can be used to examine the inside lining of the urethra (the hollow tube-shaped organ through which urine flows through the bladder and out of the body) and the bladder. It can also be used to take tissue samples for analysis to detect the possible presence of cancer cells.

What does it mean when you feel pain in your bone?

The symptom of bone pain refers to feelings of pain, tenderness, aching, or discomfort in the bone . 1,2 To find out what may be causing bone pain, healthcare providers usually perform a physical evaluation in addition to other types of testing to help make a diagnosis.

Why does my bone hurt?

There are multiple causes of bone pain, including. Fracture due to injury or accident. Infection. Osteo porosis. Other types of cancer, including leukemia. Overuse of the bone. By providing your email address, you are agreeing to our privacy policy. We never sell or share your email address.

Can you urinate if your bladder is full?

Urgently needing to urinate despite a bladder that is not full. Not being able to urinate, even if your bladder is full. Let your healthcare provider know if you are experiencing bone pain. While bladder cancer is not a very common reason, it is important to diagnose and treat the cause.

How to treat metastatic bladder cancer?

Treatment for metastatic bladder cancer may involve a combination of chemotherapy treatments with or without surgery or radiation. Systemic chemotherapy is typically used as first-line treatment for metastatic bladder cancer, but this can vary for each person. Systemic means the chemotherapy drugs target the cancer cells, but all of the cells in your body are also exposed to the medicine. These drugs help stop or reduce the growth of cancer cells throughout the body. 1,5

What is it called when bladder cancer spreads to other parts of the body?

When cancer cells break away from where they started to grow and start spreading to other parts of the body, it is called metastasis . Metastatic bladder cancer is the name for bladder cancer that has spread to other parts of the body, such as the lungs, the liver, or the bones.

What is it called when cancer cells grow in the bladder?

Even if the cancer cells are first discovered in the bones, for example, if they first started growing in the bladder it is still called metastatic bladder cancer. 1.

How to diagnose bladder cancer?

A cystoscopy is the main test used to identify and diagnose bladder cancer. During the procedure, a cystoscope (lighted telescope) is inserted into your bladder from the urethra so your doctor can view the inside of your bladder. If the procedure is done under anesthesia, your doctor can also take a biopsy (tissue samples) so they can examine it for signs of cancer. If the tests find cancer cells or tumors in the bladder, then more tests will likely be needed to find out if there are bladder cancer cells in other parts of the body. 3

What is bladder cancer made of?

Metastatic Bladder Cancer. The bladder is a flexible, hollow organ that is mostly made of muscle, but it has a thin layer of cells lining the inside of the bladder walls called the urothelium. In most patients with bladder cancer, the cancer cells started to grow in this inner lining of the bladder. As the number of cancer cells grows, they can …

How long does bladder cancer last?

The 5-year relative survival rates for people with distant bladder cancer, meaning the cancer has spread to distant parts of the body such as the lungs, liver, or bones, is about 5 percent. This means that people with metastatic bladder cancer are, on average, about 5 percent as likely as people who do not have this form …

What are the symptoms of bladder cancer?

Lower back and abdominal pain. Swelling in the feet. Fatigue and weakness. Decreased appetite and weight loss. Bone pain. Let your doctor know right away if you are experiencing these symptoms. If your doctor thinks your symptoms may be caused by bladder cancer, you will need to have tests performed.

Why are bone metastases important?

The presence of bone metastases is a sign of disseminated disease and foretells a short-term prognosis in cancer patients. The bone metastases have an important impact on patient’s quality of life so, new strategies are necessary to prevent skeletal disease and palliate established skeletal events.

Which cancer is the third most common site of metastasis?

Bone is the third most frequent site of metastasis, behind lung and liver.3Prostate and breast cancer (BC) are responsible for the majority of the skeletal metastases (up to 70%).4This reflects both the high incidence and relatively long clinical course of these tumors.

What is osteolytic metastasis?

Osteolytic, characterized by destruction of normal bone, present in multiple myeloma (MM), renal cell carcinoma, melanoma, non-small cell lung cancer, non-hodgkin lymphoma, thyroid cancer or langerhans-cell histiocytosis. The great majority of BC produces osteolytic metastases. This bone destruction is primarily mediated by osteoclasts and not a direct effect of tumor cells.5,6Other way, with lesser importance, is the compression of vasculature and consequent ischaemia in the late stages of cancer.3Parathyroid hormone-related peptide (PTHrP) has a major role in the development of osteolytic lesions.7It is unclear if bone microenvironment induces cancer cells to express PTHrP or if cells that metastasize to bone have an intrinsic higher PTHrP expression.8The receptor activator of NF-kappaB ligand (RANKL) play a critical role in the formation of osteoclasts by stimulating precursor cells when binds to receptor activator of NF-kappaB (RANK) on the cell membrane of osteoclast precursors.9

Why are medullary lesions more difficult to detect than lesions in cortical bone?

Medullary lesions are more difficult to detect than lesions in cortical bone because of the limited contrast in trabecular bone.35Osteolytic lesions appear as a darker hole in the gray-white bone image; osteoblastic lesions appear as spots that are whiter than the bone around them.

How long does prostate cancer last?

In prostate cancer, men with a good performance status and bone only disease, affecting predominantly the axial skeleton, have a median duration of disease control after androgen blockade of 4years and a median survival of 53 months.

What are the most common metabolic complication of malignant disease?

Hypercalcaemia is the most common metabolic complication of malignant disease.28It is frequent in squamous-cell carcinomas of the lung, BC and kidney, MM and lymphoma. The four main contributes are: focal osteolysis by tumor cells, generalized osteolysis by humoral factors secreted by the tumor, increased renal tubular reabsorption of calcium and impaired renal glomerular function. BC secretes PTHrP; MM leads to impaired renal function due to deposition of Bence-Jones proteins; some lymphomas produce active metabolites of vitamin-D, which increases both bone resorption and intestinal absorption of calcium.28

How long does it take to recover from bone metastasis?

The median-survival from diagnosis of bone metastasis is: 6months in melanoma; 6-7 months in lung; 6-9 months in bladder; 12 months in renal cells carcinoma; 12-53 months in prostate; 19-25 months in BC and 48 months in thyroid.5.

How to treat bone metastases?

Sometimes treatment being used to treat the main (primary) cancer will help shrink the metastases. Other times, medicines made to stop the effects of the cancer on the bone may be given (See Drugs to treat bone metastases below). In addition, some more local treatments , like radiation therapy or even surgery, can help relieve the pain.

What are the most common sites of bone metastases?

Almost all cancers can spread to the bone, but cancers that often spread there include breast, lung, prostate, kidney, melanoma, ovarian, and thyroid . The spine is the most common site for bone metastases. Other common sites are the hip bone (pelvis), upper leg bone (femur), upper arm bone (humerus), ribs, and the skull.

What is the best treatment for bone metastasis?

The drugs used most often for treating bone problems in people with bone metastases are the bisphosphonate drugs pamidronate (Aredia) and zoledronic acid (Zometa) and the drug denosumab (Xgeva, Prolia). These drugs are given intravenously (IV or into a vein) or subcutaneously (under the skin). Most patients are treated once a month at first, but may be able to be treated less often later on if they are doing well. Treatment with one of these drugs can help prevent further bone damage and events related to weakened bones such as fractures, hypercalcemia, and spinal cord compression.

What is a broken bone?

Fractures (broken bones or breaks) Breaks might happen with a fall or injury, but a weak bone can also break during normal activities. These breaks often cause sudden, severe pain. Fractures most often happen in the long bones of the arms and legs and the bones of the spine. Sudden pain in the middle of the back, for instance, …

Why do cancer cells make bones stronger?

This helps keep the bones strong. When cancer cells block or speed up the action of the osteoblasts and osteoclasts, too much bone is broken down or too much bone is made. Either of these changes can make bones break easier …

Can bone cancer spread to bone?

Bone pain is often the first symptom of cancer that has spread to the bone . The pain may come and go at first. It tends to be worse at night and may get better with movement. Later on, it can become constant and may be worse during activity. The bone might be so weak that it will break.

Can radiation make bone stronger?

Radiation treatments may be given after surgery to try to prevent any more damage. The radiation won’t make the bone stronger, but it might stop further damage. If you feel confused, dizzy, or weak, talk with your cancer care team about safety equipment you can use at home, such as shower chairs, walkers, or handrails.

How does cancer metastasize to bones?

The exact mechanism of how cancer cells metastasize to the bones isn’t fully known. It’s a very active area of scientific research. New understanding of how metastasis works is continuing to lead to new methods of treatment.

Why is bone metastasis called metastatic?

It’s also called metastatic bone disease or secondary bone cancer, because the cancer didn’t start in the bones. in people who have been previously diagnosed with cancer or who have advanced cancer. But sometimes the pain of bone metastasis may be the first sign of cancer.

How do survival rates for bone metastases vary?

Survival rates of bone metastases. Survival rates for people with bone metastases vary greatly by cancer type and stage. Your general health condition and the type of treatment you received for the primary cancer are additional factors. Discuss your particular situation with your doctor.

What cancers can spread to bone?

The most common cancers that spread to bone are breast, prostate, and lung. But many other cancers can metastasize to bone, including: for cancer to spread. The lungs and liver are the first two. Cancer cells may metastasize to only one of your bones or to many at the same time.

How soon after breast cancer diagnosis can you start bone targeting?

A breast cancer study reported a lower risk of bone complications for people who started treatment within 6 months of a bone metastasis diagnosis.

What is the process of breaking down old bone tissue into minerals that circulate in your blood called?

New bone tissue is being formed and old bone tissue is breaking down into minerals that circulate in your blood. This process is called remodeling. Cancer cells upset the normal process of bone remodeling, causing bones to become weak or too dense, depending on the type of bone cells affected.

Which cancer has the lowest survival rate?

Lung cancer had the lowest 1-year survival rate after bone metastasis (10 percent). Breast cancer had the highest 1-year survival rate after bone metastasis (51 percent). Having metastases in bone and also in other sites was found to decrease the survival rate.

Where Bladder Cancer Can Spread

Symptoms and Complications

Treatment Options

Living with Bladder Cancer



  • Metastatic bladder cancer is cancer that has spread outside of the bladder to other parts of the body. If you have metastatic bladder cancer, your treatment will be focused on destroying or slowing down cancer cells throughout your body, not just in your bladder. There are several treatments for this disease. Chemotherapy is usually the first-line …

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