is thickening of bladder wall cancer



Metastatic bladder cancer showing diffuse thickening of the bladder wall is very rare. We report two cases of metastatic bladder cancer arising from a stomach cancer and acute lymphocytic leukemia. Hydronephrosis and diffuse thickening of the bladder wall were revealed by ultrasonography and computed tomography.

From their data, they discovered: * A mass in the bladder has a 50-percent chance of being cancerous. * A bladder wall that was uniformly thicker than usual had a 20-percent chance of being cancerous. * A bladder with a localized area of thickness on the inside wall is not likely to be cancerous.Aug 10, 2015


What does a thickening of the bladder wall mean?

 · Bladder wall thickening dose not = cancer as there are many things that can cause it. I have had a CT 4 years ago and it showed bladder wall thickening. I went to see a urologist where he checked with his scope. There was noting. He so a mildly inlarged prostate which can put pressure on the bladder and cause the wall to thicken.

Is uterine wall thickening a harbinger of cancer?

 · Go to the Kidney & Bladder group. Hello @david2dave and welcome to Mayo Clinic Connect. As I read your post, I’m assuming that you are experiencing this problem, is that correct? I did a google search and found an article that listed several reasons for …

Is chronic gallbladder wall thickening a malignant condition?

“Mild thickening of bladder wall” was on my CT, and follow-up TURBT revealed that my Stage 1/high grade cancer had returned. This was my finding, do not presume that it will be yours. You do not need to be alarmed, just be proactive. EMMYHARRISON Member Posts: 2 …

What is bladder cancer?

 · As a result of certain conditions, the bladder wall thickens. Thickened bladder wall causes could be any of the following: Inflammation due to urinary tract infection can cause thickening. This is because the infected tissue accumulates fluids, pus, and other inflammatory debris that makes it swell and look dense. Benign, non-cancerous tissue growths such as …


What does thickening of bladder wall indicate?

One of the major responses to a UTI is inflammation of the bladder wall, a condition known as cystitis. Prolonged inflammation can lead to thickening of the wall. Some other causes of cystitis include inflammation triggered by cancer treatments, like radiation and chemotherapy, or prolonged use of a catheter.

What are the warning signs of bladder cancer?

Bladder Cancer: Symptoms and SignsBlood or blood clots in the urine.Pain or burning sensation during urination.Frequent urination.Feeling the need to urinate many times throughout the night.Feeling the need to urinate, but not being able to pass urine.Lower back pain on 1 side of the body.

What is the treatment for bladder wall thickening?

Increased intravesical pressure results from smooth muscle hypertrophy and thus the bladder wall thickens. Alpha-blocker therapy is the most preferred medical treatment in patients with LUTS. Bladder wall hypertrophy is caused by a thickening of the detrusor.

What are the symptoms of first stage bladder cancer?

Changes in bladder habits or symptoms of irritationHaving to urinate more often than usual.Pain or burning during urination.Feeling as if you need to go right away, even when your bladder isn’t full.Having trouble urinating or having a weak urine stream.Having to get up to urinate many times during the night.

Does bladder cancer show on CT scan?

A CT scan uses X-rays and a computer to create three-dimensional, cross-sectional pictures of the bladder, as well as the ureters and kidneys. A CT scan may be used to see whether bladder cancer has invaded the bladder wall or has spread to other organs or nearby lymph nodes.

Does ultrasound show bladder cancer?

Bladder cancer can show up on ultrasound, but ultrasound is infrequently used to help make a diagnosis of a bladder tumor. CAT scans are more often used along with cystoscopy to detect bladder cancers.

What is normal bladder wall thickness?

The normal bladder wall had a mean thickness of 2.76 mm when the bladder is almost empty and 1.55 mm when it is distended. There is a linear relationship between bladder fullness and bladder wall thickness; the upper limits are 3 and 5 mm for a full or empty bladder respectively.

Are bladder tumors usually cancerous?

Bladder cancer or bladder tumors are relatively common in the United States, and most bladder tumors are cancerous.

What percentage of bladder tumors are benign?

“While there are several types of benign masses that can grow in the bladder, these are uncommon and account for fewer than 1% of bladder masses,” says Khurshid Guru, MD, Chair of Roswell Park’s Department of Urology.

Which of the following is the most common symptom of cancer of the bladder?

Blood in your urine is the most common symptom of bladder cancer. The medical name for blood in your urine is haematuria and it’s usually painless. You may notice streaks of blood in your urine or the blood may turn your urine brown. The blood isn’t always noticeable and it may come and go.

Can you have bladder cancer for years and not know it?

It may be seen as a symptom of post-menopausal bleeding, simple cystitis or a urinary tract infection. As a result, a bladder cancer diagnosis can be overlooked for a year or more.

How quickly does bladder cancer spread?

As many as 50% of patients with muscle-invasive bladder cancer may have occult metastases that become clinically apparent within 5 years of initial diagnosis and around 5% will have distant metastasis at the time of initial diagnosis. Most patients with overt metastatic disease die within 2 years despite chemotherapy.


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The Bladder Cancer Advocacy Network Support Community connects patients, families, friends and caregivers for support and inspiration. This community is sponsored by the Bladder Cancer Advocacy Network, an Inspire trusted partner.

Why does the bladder wall thicken?

As a result of certain conditions, the bladder wall thickens. Inflammation due to urinary tract infection can cause thickening. This is because the infected tissue accumulates fluids, pus, and other inflammatory debris that makes it swell and look dense.


How to cure a urinary tract infection?

Urinary tract infection can be cured from adapting an acidic diet (to acidify the urine), increasing fluid intake, proper hygiene, take pain relievers, avoiding caffeine and foods that irritate the bladder, and antibiotics prescribed by your doctor.

Can a doctor remove a tumor?

As for tumors, your doctor might prescribe medications to dissolve it or you may choose to have it removed through surgery.

Can cancer cause tumors?

Benign, non-cancerous tissue growths such as tumor can also be a cause. One very dangerous cause is a cancer. The hallmark of cancer is malignancy where there is a rapid tissue growth that might cause thickening.


What is bladder cancer?

Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder. Symptoms include blood in the urine, pain with urination, and low back pain. It is caused when epithelial cells that line the bladder become malignant.

Which lymph nodes drain bladder cancer?

The most common sentinel lymph nodes draining bladder cancer are obturator and internal iliac lymph nodes. The location of lymphatic spread depends on the location of the tumors. Tumors on the superolateral bladder wall spread to external iliac lymph nodes.

How to treat non-muscle invasive bladder cancer?

Non-muscle invasive bladder cancer (those not entering the muscle layer of the bladder) can be “shaved off” using an electrocautery device attached to a cystoscope, which in that case is called a resectoscope. The procedure is called transurethral resection of bladder tumor (TURBT) and serves primarily for pathological staging. In case of non-muscle invasive bladder cancer the TURBT is in itself the treatment, but in case of muscle invasive cancer, the procedure is insufficient for final treatment. Additionally, blue light cystoscopy with optical-imaging agent Hexaminolevulinate (HAL) is recommended at initial TURBT to increase lesion detection (especially carcinoma in situ) and improve resection quality thereby reducing recurrence. It is important to assess the quality of the resection, if there is evidence of incomplete resection or there is no muscle in the specimen (without which muscle invasiveness cannot be determined) a second TURBT is strongly recommended. Moreover, nearly half of the people with high grade non-invasive disease have residual tumor after primary TURBT, in such cases a second TURBT is important for avoiding under-staging. At this point classifying people into risk groups is recommended. Treatment and surveillance for different risk groups is indicated in the table below.


What are the risk factors for bladder cancer?

Risk factors for bladder cancer include smoking, family history, prior radiation therapy, frequent bladder infections, and exposure to certain chemicals. The most common type is transitional cell carcinoma. Other types include squamous cell carcinoma and adenocarcinoma. Diagnosis is typically by cystoscopy with tissue biopsies. Staging of the cancer is determined by transurethral resection and medical imaging.

What are the genes that cause bladder cancer?

Mutations in FGFR3, TP53, PIK3CA, KDM6A, ARID1A, KMT2D, HRAS, TERT, KRAS, CREBBP, RB1 and TSC1 genes may be associated with some cases of bladder cancer. Deletions of parts or whole of chromosome 9 is common in bladder cancer. Low grade cancer are known to harbor mutations in RAS pathway and the fibroblast growth factor receptor 3 (FGFR3) gene, both of which play a role in the MAPK/ERK pathway. p53 and RB gene mutations are implicated in high-grade muscle invasive tumors. Eighty nine percent of muscle invasive cancers have mutations in chromatin remodeling and histone modifying genes. Deletion of both copies of the GSTM1 gene has a modest increase in risk of bladder cancer. GSTM1 gene product glutathione S-transferase M1 (GSTM1) participates in the detoxification process of carcinogens such as polycyclic aromatic hydrocarbons found in cigarette smoke. Similarly, mutations in NAT2 ( N-acetyltransferase) is associated with increased risk for bladder cancer. N-acetyltransferase helps in detoxification of carcinogens like aromatic amines (also present in cigarette smoke). Various single-nucleotide polymorphisms in PSCA gene present on chromosome 8 have shown to increase the risk for bladder cancer. PSCA gene promoter region has an androgen response region. Loss of reactivity of this region to androgens is hypothesized as a cause of more number of aggressive tumors in women (unlike in men who have higher amount of androgen).

How long does it take for bladder cancer to go away?

Risk of bladder cancer decreases by 30% within 1–4 years and continues to decrease by 60% at 25 years after smoking cessation. However, former smokers will most likely always be at a higher risk of bladder cancer compared to people who have never smoked. Passive smoking also appear to be a risk.


How many cigarettes a day can you smoke to get bladder cancer?

A risk plateau at smoking about 15 cigarettes a day can be observed (meaning that those who smoke 15 cigarettes a day are approximately at the same risk as those smoking 30 cigarettes a day).

What cancer begins with a thickened uterine lining?

And in fact, uterine (endometrial) cancer in most cases begins with a thickened uterine lining.

Can endometrial cancer be diagnosed from ultrasound?

Risk Factors for Endometrial Hyperplasia. No matter how thick the uterine lining is, a diagnosis of cancer cannot be made based on the measurement from an ultrasound. Only a biopsy can confirm cancer. For additional information on endometrial cancer, contact Cancer Treatment Centers of America at (844) 632-7188.


Can hyperplasia cause cancer?

However, Dr. Schink adds, “Hyperplasia unresolved for years can result in endometrial cancer. Thickening of the uterine lining is often just benign hyperplasia, or it can be from benign uterine polyps.”.

Can uterine cancer be detected with pelvic ultrasound?

But this doesn’t mean that every case of uterine wall thickening is a harbinger for cancer.

Is endometrial hyperplasia a sign of cancer?

Endometrial Hyperplasia: a Thickened Uterine Wall. This is thickening of the uterine lining and it is not always a sign of cancer , even though, as Dr. Schink points out, it can eventually lead to malignancy.

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