where can bladder cancer spread to

What are the chances of dying from bladder cancer?

Once cancerous cells have reached the lymphatic system, they can make their way to almost any part of the body. However, the most common sites for distant bladder cancer metastases include the: Lungs; Bones; Liver; Metastatic bladder cancer can also spread to other organs in the urinary and reproductive tracts, such as the prostate, uterus and vagina. How is metastatic bladder …

How dangerous is bladder cancer?

 · Cancer cells can spread to other parts of the body. For instance, cancer cells in the bladder can travel to the bone and grow there. When cancer cells spread, it’s called metastasis. Cancer is always named for the place where it starts. So when bladder cancer spreads to the bone (or any other place), it’s still called bladder cancer.

What is the survival rate for Stage 3 bladder cancer?

Bladder cancer can spread through the tissue to nearby organs, such as the prostate (men) or vagina (women). It can also spread through the lymph system, by traveling through lymph vessels to lymph nodes in different parts of the body. It can also spread through the body’s blood vessels and form tumors in other parts of the body, such as the bones or lungs.

What are the signs that bladder cancer has spread?

The signs and symptoms of bladder cancer that has spread to other parts of the body include:tiredness or weakness.pain when urinating.difficulty urinating or inability to urinate.pain in the lower back on one side of the body.weight loss.swollen feet.bone pain.

Is it common for bladder cancer to spread?

Low-grade bladder cancers look a lot like normal bladder cells. They tend to grow and spread slowly. High-grade bladder cancers look less like normal bladder cells. These cancers are more likely to grow and spread.

Where does invasive bladder cancer spread?

Over time, the cancer may grow outside the bladder into tissues close by. Bladder cancer may spread to lymph nodes nearby and farther away. The cancer may reach the bones, the lungs, or the liver and other parts of the body.

How quickly does bladder cancer metastasize?

As many as 50% of patients with muscle-invasive bladder cancer may have occult metastases that become clinically apparent within 5 years of initial diagnosis and around 5% will have distant metastasis at the time of initial diagnosis. Most patients with overt metastatic disease die within 2 years despite chemotherapy.

Which lymph nodes does bladder cancer spread to?

Bladder cancer can spread this way. If it does, it usually first spreads to the lymph nodes in the pelvis around the bladder (called perivesicular lymph nodes). From there, it can spread to lymph nodes that are close to major blood vessels that run into the leg and pelvis.

Does bladder cancer spread to lungs?

It’s not uncommon for bladder cancer to metastasize to the lungs, liver or bones. This can cause pain and other symptoms in distant parts of the body. In many cases, metastatic bladder cancer also causes general complications such as fatigue and weight loss.

What happens if bladder cancer spread to lymph nodes?

Once bladder cancer has reached the lymph nodes, it can travel to distant parts of the body through the lymphatic system. Separately, it can also continue to grow into surrounding areas such as the abdominal wall (peritoneum).

Can bladder cancer spread to the hip bone?

Bladder cancer that spreads to the bones is called secondary bone cancer. You might have different treatments to help strengthen your bones and prevent problems.

Can bladder cancer spread to legs?

Though bone metastases have been observed with bladder cancer, they are considerably less common when compared to prostate and breast cancer. Common bone metastases sites for bladder carcinoma include pelvis and spine [2]. Our case reports an unusual metastasis to the tibia.

Can bladder cancer spread to the pancreas?

Bladder cancer usually metastasizes to lymph node, bone, and liver but metastasis to pancreas is very rare. We present a rare case of metastatic bladder carcinoma to Pancreas which was successfully managed with biliary stent placement.

Does bladder cancer spread to colon?

The common sites of metastasis from a urinary bladder carcinoma include lymph nodes, bones, lung, liver, and peritoneum. Only a few cases of small bowel metastasis from urinary bladder malignancy have been reported in the English literature. Only one of these cases presented with bowel intussusception.

Does bladder cancer spread to the brain?

Bladder cancer is known to metastasize to multiple sites of the body but rarely to the brain. When it does metastasize to the brain the prognosis is poor with median survival of 2-4 months despite treatment [8,9].

How Does The Doctor Know I Have Bladder Cancer?

Bladder cancer might cause symptoms such as: 1. Having trouble peeing 2. Feeling pain when peeing 3. Needing to go more often than normal 4. Seeing…

Tests to Look For Bladder Cancer

Your doctor may do other tests to find out more about the cancer. Some of them are:X-ray: Dye is put into a vein for a special x-ray of the kidneys…

How Serious Is My Cancer?

If you have bladder cancer, the doctor will want to find out how far it has spread. This is called staging. Your doctor will want to find out the s…

What Kind of Treatment Will I Need?

There’s more than one way to treat bladder cancer. You might want to get a second opinion about the best treatment plan for you. Doctors may have d…

What Will Happen After Treatment?

You will be glad when treatment is over. But it’s hard not to worry about cancer coming back. Even when cancer never comes back, people still worry…

Where is the bladder located?

The bladder is a hollow organ that stores urine before it leaves your body. It sits in the lowest part of your belly, called your pelvis. Urine is made in your kidneys. Tubes called ureters connect your kidneys to the bladder. Urine flows through the ureters and into your bladder, where it’s stored. When you urinate (pee), the bladder squeezes the urine out through a tube called the urethra.

What is it called when cancer cells spread to other parts of the body?

For instance, cancer cells in the bladder can travel to the bone and grow there. When cancer cells spread, it’s called metastasis . Cancer is always named for the place where it starts.

How do you know if you have bladder cancer?

Signs of bladder cancer are problems peeing, pain when peeing, needing to go more often than normal, and seeing blood in your urine

What is the best test to find out if you have bladder cancer?

Ultrasound: This test uses sound waves to make pictures of the organs inside your body, like your bladder and kidneys. It can help show the size of a bladder cancer and if it has spread. Bone scan: A bone scan can help show if bladder cancer has spread to the bones. This test is not done unless you have bone pain.

What tests are done to check for bladder cancer?

This might include a rectal exam, during which a gloved finger is put into your rectum. If you are a woman, a pelvic exam might also be done.

Where does urine go when you pee?

Urine flows through the ureters and into your bladder, where it’s stored. When you urinate (pee), the bladder squeezes the urine out through a tube called the urethra. Bladder cancer usually starts in the lining or inner layer of the bladder wall.

Can a test show if bladder cancer is growing?

Tests can show how deeply the cancer has grown into the bladder wall.

How does bladder cancer spread?

It can also spread through the lymph system, by traveling through lymph vessels to lymph nodes in different parts of the body. It can also spread through the body’s blood vessels and form tumors in other parts of the body, …

What tests determine if bladder cancer has spread?

What Tests Determine Cancer Spread? When a patient is diagnosed with bladder cancer, healthcare providers may carry out further tests to find out if the bladder cancer cells have spread to other organs or parts of the body. 1,2 Bladder cancer that has spread ( metastasized) is called metastatic bladder cancer. …

Can a retrograde pyelogram detect bladder cancer?

For example, intravenous or retrograde pyelograms are types of x-rays that use a special dye to highlight the organs of the urinary tract. This can make it possible to detect cancer that has spread to the kidneys, ureters, or other parts of the urinary tract. If healthcare providers suspect that the bladder cancer may have spread to …

How does bladder cancer affect survival?

The factors influencing survival include: 1 Age: Increasing age has been linked to a lower survival rate in people with bladder cancer. 7 2 Sex: A literature review of 27 studies and 23,754 patients found that women had a greater risk for disease recurrence following localized treatment of non-muscle-invasive bladder cancer. 8 3 Smoking: Smoking increases the risk of recurrence and mortality in people with bladder cancer. 9 4 Recurrence: Recurrence of bladder cancer forebodes a poor prognosis, with a median survival of six months after recurrence. Although people with local recurrence have a slightly better prognosis, those with disease recurrence at local and distant sites perform very poorly.

How many people will die from bladder cancer in 2020?

Bladder cancer is the sixth most common cancer in the United States, representing 4.5% of all new cancer cases in the country. 1 There were an estimated 81,400 new cases of bladder cancer in 2020. This form of cancer resulted in about 17,980 deaths in the same year. While bladder cancer is relatively common, the average five-year survival rate is quite high at 76.9%. This rate has improved over the past several years, and a person’s chance of survival is influenced by many factors.

What is the prognosis of bladder cancer?

Prognosis describes how severe a person’s cancer is and their chances of survival. It is influenced by factors that are not reflected in the SEER survival statistics. Chief among them are the type, stage, and grade of bladder cancer. Other factors also contribute.

What is the function of the bladder?

The bladder is flexible, being made of smooth muscle. It works to collect and then eliminate urine from your body. The bladder’s flexible walls are made perfectly to expand and contract as necessary to hold urine until it is expelled from the body.

How many stages of cancer are there in TNM?

Its purpose is to measure and communicate the extent of tumor growth. There are five TNM stages, from 0 to 4. The lower the stage number, the smaller the spread of cancer.

What is the difference between localized and distant cancer?

These rates are classified by stage: localized, regional, and distant. Cancer is considered localized when it is only found in the part of the body where it started. Regional means the cancer has spread to nearby lymph nodes or organs and tissues, while distant refers to cancer that has metastasized to distant organs or lymph nodes.

Is bladder cancer muscle invasive?

Approximately 20% of newly diagnosed bladder cancer cases are muscle-invasive. 5. Non-muscle-invasive bladder cancer: The cancer in this case is confined to the inner surface of the bladder and does not involve the bladder muscle. Some cases may progress to muscle-invasive bladder cancer.

Where does bladder cancer spread?

Lymph nodes in the pelvis. Bladder cancer commonly spreads to obturator and internal iliac (not labelled)

Where is the highest rate of bladder cancer?

In 2018, the highest rate of bladder cancer occurred in Southern and Western Europe followed by North America with rates of 15, 13, and 12 cases per 100,000 people. The highest rates of bladder cancer deaths were seen in Northern Africa and Western Asia followed by Southern Europe.

How to treat non-muscle invasive bladder cancer?

Non-muscle invasive bladder cancer (those not entering the muscle layer of the bladder) can be “shaved off” using an electrocautery device attached to a cystoscope, which in that case is called a resectoscope. The procedure is called transurethral resection of bladder tumor (TURBT) and serves primarily for pathological staging. In case of non-muscle invasive bladder cancer the TURBT is in itself the treatment, but in case of muscle invasive cancer, the procedure is insufficient for final treatment. Additionally, blue light cystoscopy with optical-imaging agent Hexaminolevulinate (HAL) is recommended at initial TURBT to increase lesion detection (especially carcinoma in situ) and improve resection quality thereby reducing recurrence. It is important to assess the quality of the resection, if there is evidence of incomplete resection or there is no muscle in the specimen (without which muscle invasiveness cannot be determined) a second TURBT is strongly recommended. Moreover, nearly half of the people with high grade non-invasive disease have residual tumor after primary TURBT, in such cases a second TURBT is important for avoiding under-staging. At this point classifying people into risk groups is recommended. Treatment and surveillance for different risk groups is indicated in the table below.

What are the risk factors for bladder cancer?

Risk factors for bladder cancer include smoking, family history, prior radiation therapy, frequent bladder infections, and exposure to certain chemicals. The most common type is transitional cell carcinoma. Other types include squamous cell carcinoma and adenocarcinoma. Diagnosis is typically by cystoscopy with tissue biopsies. Staging of the cancer is determined by transurethral resection and medical imaging.

What are the genes that cause bladder cancer?

Mutations in FGFR3, TP53, PIK3CA, KDM6A, ARID1A, KMT2D, HRAS, TERT, KRAS, CREBBP, RB1 and TSC1 genes may be associated with some cases of bladder cancer. Deletions of parts or whole of chromosome 9 is common in bladder cancer. Low grade cancer are known to harbor mutations in RAS pathway and the fibroblast growth factor receptor 3 (FGFR3) gene, both of which play a role in the MAPK/ERK pathway. p53 and RB gene mutations are implicated in high-grade muscle invasive tumors. Eighty nine percent of muscle invasive cancers have mutations in chromatin remodeling and histone modifying genes. Deletion of both copies of the GSTM1 gene has a modest increase in risk of bladder cancer. GSTM1 gene product glutathione S-transferase M1 (GSTM1) participates in the detoxification process of carcinogens such as polycyclic aromatic hydrocarbons found in cigarette smoke. Similarly, mutations in NAT2 ( N-acetyltransferase) is associated with increased risk for bladder cancer. N-acetyltransferase helps in detoxification of carcinogens like aromatic amines (also present in cigarette smoke). Various single-nucleotide polymorphisms in PSCA gene present on chromosome 8 have shown to increase the risk for bladder cancer. PSCA gene promoter region has an androgen response region. Loss of reactivity of this region to androgens is hypothesized as a cause of more number of aggressive tumors in women (unlike in men who have higher amount of androgen).

How long does it take for bladder cancer to go away?

Risk of bladder cancer decreases by 30% within 1–4 years and continues to decrease by 60% at 25 years after smoking cessation. However, former smokers will most likely always be at a higher risk of bladder cancer compared to people who have never smoked. Passive smoking also appear to be a risk.

How many cigarettes a day can you smoke to get bladder cancer?

A risk plateau at smoking about 15 cigarettes a day can be observed (meaning that those who smoke 15 cigarettes a day are approximately at the same risk as those smoking 30 cigarettes a day).