what cause bladder cancer

Contents

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Symptoms

Researchers do not know exactly what causes most bladder cancers. But they have found some risk factors (see Bladder Cancer Risk Factors ) and are starting to understand how they cause cells in the bladder to become cancer. Certain changes in the DNA inside normal bladder cells can make them grow abnormally and form cancers.

Causes

Learn about the risk factors for bladder cancer and what you might be able to do to help lower your risk. Bladder Cancer Causes, Risk Factors, and Prevention The American Cancer Society is here to support Ukrainian patients with cancer, caregivers, and clinicians.

Prevention

Dec 06, 2021 · Smoking is a leading cause of cancer, including bladder cancer. In fact, smoking cigarettes, cigars, or pipes is thought to contribute to around half of all bladder cancer cases. This is because toxic chemicals from tobacco smoke pass into the bloodstream from the lungs. The blood then travels to the kidneys to be filtered.

Complications

Certain industrial chemicals have been linked with bladder cancer. Chemicals called aromatic amines, such as benzidine and beta-naphthylamine, which are sometimes used in the dye industry, can cause bladder cancer. Workers in other industries that use certain organic chemicals also may have a higher risk of bladder cancer.

What are the chances of getting bladder cancer?

Apr 15, 2021 · Bladder cancer refers to the uncontrolled cell growth that begins in the bladder. This happens when an abnormal change (a mutation) in the deoxyribonucleic acid (DNA) causes the DNA to malfunction. The DNA is the one that instructs the cells when to divide, grow, or die.

How dangerous is bladder cancer?

Nov 03, 2020 · Smoking is the main risk factor for bladder cancer, and is responsible for about half of all bladder cancers in both men and women Workplace exposures to certain chemicals Aromatic amines, such as benzidine and beta-naphthylamine, sometimes used in the dye industry Makers of rubber, leather, textiles, paint products, and printing companies

What are the most common symptoms of bladder cancer?

More often it’s caused by other things like an infection, benign (not cancer) tumors, stones in the kidney or bladder, or other benign kidney diseases. Still, it’s important to have it checked by a doctor so the cause can be found. Changes in bladder habits or symptoms of irritation. Bladder cancer can sometimes cause changes in urination, such as:

What is the risk factor of bladder cancer?

2 days ago · Infection with Schistosoma haematobium (bilharzia or schistosomiasis) may cause bladder cancer, specially of the squamous cell type. Schistosoma eggs induces a chronic inflammatory state in the bladder wall resulting in tissue fibrosis. Higher levels of N-nitroso compounds has been detected in urine samples of people with schistosomiasis.

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How does bladder cancer develop?

Bladder cancer develops when cells in the bladder begin to grow abnormally, forming a tumor in the bladder. Bladder cancer begins when cells in the bladder develop changes (mutations) in their DNA. A cell’s DNA contains instructions that tell the cell what to do.

Where does bladder cancer start?

Bladder cancer is a common type of cancer that begins in the cells of the bladder. The bladder is a hollow muscular organ in your lower abdomen that stores urine. Bladder cancer most often begins in the cells (urothelial cells) that line the inside of your bladder. Urothelial cells are also found in your kidneys and the tubes (ureters) …

Where is the bladder located?

Your kidneys, located in the rear portion of your upper abdomen, produce urine by filtering waste and fluid from your blood. Bladder cancer is a common type of cancer that begins in the cells of the bladder. The bladder is a hollow muscular organ in your lower abdomen that stores urine. Bladder cancer most often begins in …

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Where is urothelial cancer found?

Urothelial cells are also found in your kidneys and the tubes (ureters) that connect the kidneys to the bladder. Urothelial cancer can happen in the kidneys and ureters, too, but it’s much more common in the bladder. Most bladder cancers are diagnosed at an early stage, when the cancer is highly treatable.

Can bladder cancer come back?

But even early-stage bladder cancers can come back after successful treatment. For this reason, people with bladder cancer typically need follow-up tests for years after treatment to look for bladder cancer that recurs.

How do you know if you have bladder cancer?

Bladder cancer signs and symptoms may include: Blood in urine (hematuria), which may cause urine to appear bright red or cola colored, though sometimes the urine appears normal and blood is detected on a lab test. Frequent urination. Painful urination. Back pain.

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What is the most common type of bladder cancer?

Urothelial carcinoma is the most common type of bladder cancer in the United States. Squamous cell carcinoma. Squamous cell carcinoma is associated with chronic irritation of the bladder — for instance, from an infection or from long-term use of a urinary catheter. Squamous cell bladder cancer is rare in the United States.

Risk Factors

A risk factor is anything that affects your chance of getting a disease such as cancer. Learn more about the risk factors for bladder cancer.

Prevention

There’s no way to completely prevent cancer. But there are things you can do that might help lower your risk. Learn more.

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How do you know if you have bladder cancer?

What Are the Symptoms of Bladder Cancer? 1 Blood in the urine. This is the most common symptom. 2 Having to urinate often. 3 Pain while urinating. 4 Back pain. 5 Pelvic pain.

What is the data visualization tool?

The Data Visualizations tool makes it easy for anyone to explore and use the latest official federal government cancer data from United States Cancer Statistics. It includes the latest cancer data covering the U.S. population.

What are the risk factors for bladder cancer?

Bladder Cancer Risk Factors. A risk factor is anything that affects your chance of getting a disease such as cancer. Different cancers have different risk factors. You can change some risk factors, like smoking or weight ; others, like your age or family history, you can’t. But having a risk factor, or even many, …

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Why do people with bladder cancer have a higher risk of getting it themselves?

Sometimes this may be because the family members are exposed to the same cancer-causing chemicals (like those in tobacco smoke). They may also share changes in some genes (like GST and NAT) that make it hard for their bodies to break down certain toxins, which can make them more likely to get bladder cancer.

What chemicals can cause bladder cancer?

Certain industrial chemicals have been linked with bladder cancer. Chemicals called aromatic amines, such as benzidine and beta-naphthylamine, which are sometimes used in the dye industry, can cause bladder cancer. Workers in other industries that use certain organic chemicals also may have a higher risk of bladder cancer.

Does pioglitazone cause bladder cancer?

According to the US Food and Drug Administration (FDA), use of the diabetes medicine pioglitazone (Actos ®) is linked with an increased risk of bladder cancer. The risk seems to get higher when higher doses are used.

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Does aristolochic acid cause bladder cancer?

The risk seems to get higher when higher doses are used. Dietary supplements containing aristolochic acid ( mainly in herbs from the Aristolochia family) have been linked with an increased risk of urothelial cancers, including bladder cancer.

Is drinking water a source of arsenic?

For most Americans, drinking water isn’t a major source of arsenic.

Why do people drink a lot of water?

This might be because they empty their bladders more often, which could keep chemicals from lingering in their bladder.

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Can you prevent bladder cancer?

There is no sure way to prevent bladder cancer. But you can take certain measures to lower your risk of developing it. These include the following:

Top What Is the Main Cause of Bladder Cancer? Related Articles

Bladder cancer occurs when cancerous cells, often from the lining of the bladder, begin to multiply. Find more information about bladder cancer, the stages of bladder cancer, and available treatment options.

What causes bladder cancer?

Causes of bladder cancer are often genetic, and risk factors include smoking, chemical exposure, race, age and other variables. Bladder cancer is a type of cancer that occurs when cells in the bladder become abnormal and grow out of control. Types of bladder cancers include:

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What is the most common type of bladder cancer?

Types of bladder cancers include: Urothelial carcinoma , also known as transitional cell carcinoma (TCC): the most common type of bladder cancer. Squamous cell carcinoma: only about 1% to 2% of bladder cancers are squamous cell …

What causes a swollen bladder?

Chronic bladder irritation and infections. Urinary infections ( UTIs ), kidney and bladder stones, bladder catheters left in place a long time, and other causes of chronic bladder irritation. Schistosomiasis ( bilharziasis ), parasitic worm infection that can get into the bladder.

What is the procedure for removing the bladder?

Surgical removal of all or part of the bladder (radical or partial cystectomy): for invasive bladder cancer. Reconstructive surgery after radical cystectomy: if the entire bladder is removed, patients need another way to store urine and pass it out of the body.

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How long do you live with bladder cancer?

Life expectancy for bladder cancer is often expressed in 5-year survival rates, that is, how many people will be alive 5 years after diagnosis. Bladder cancer 5-year survival rates: In situ (cancer is still confined to the cells in which it initially started and has not spread into any nearby tissue): 96%.

What does it mean when you have blood in your urine?

Blood in the urine ( hematuria) Usually the first sign of bladder cancer . Urine may appear orange, pink, or, less often, dark red. Changes in bladder habits. Bladder irritation. Urinary frequency. Pain or burning during urination. Feeling as if you need to go right away, even when the bladder isn’t full.

Why does my urine turn red?

Bladder irritation. Urinary frequency. Pain or burning during urination. Feeling as if you need to go right away, even when the bladder isn’t full. Difficulty urinating or having a weak urine stream .

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Can bladder cancer cause bleeding?

Usually, the early stages of bladder cancer (when it’s small and only in the bladder) cause bleeding but little or no pain or other symptoms. Blood in the urine doesn’t always mean you have bladder cancer.

What are the symptoms of bladder cancer?

Being unable to urinate. Lower back pain on one side. Loss of appetite and weight loss. Feeling tired or weak. Swelling in the feet. Bone pain. Again, many of these symptoms are more likely to be caused by something other than bladder cancer, but it’s important to have them checked.

How do you know if you have bladder cancer?

Bladder cancers that have grown large or have spread to other parts of the body can sometimes cause other symptoms, such as: Being unable to urinate. Lower back pain on one side. Loss of appetite and weight loss. Feeling tired or weak.

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Can bladder cancer spread to other parts of the body?

Bladder cancers that have grown large or have spread to other parts of the body can sometimes cause other symptoms, such as: Again, many of these symptoms are more likely to be caused by something other than bladder cancer, but it’s important to have them checked.

Can bladder cancer cause lower back pain?

Bladder cancers that have grown large or have spread to other parts of the body can sometimes cause other symptoms, such as: Being unable to urinate. Lower back pain on one side. Loss of appetite and weight loss. Feeling tired or weak.

What does it mean when you have blood in your urine?

Blood in the urine. In most cases, blood in the urine (called hematuria) is the first sign of bladder cancer. There may be enough blood to change the color of the urine to orange, pink, or, less often, dark red.

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Why do I have trouble peeing?

Having to get up to urinate many times during the night. These symptoms are more likely to be caused by a urinary tract infection (UTI), bladder stones, an overactive bladder, or an enlarged prostate (in men).

What is bladder cancer?

Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder. Symptoms include blood in the urine, pain with urination, and low back pain. It is caused when epithelial cells that line the bladder become malignant.

What is the treatment for bladder cancer?

Treatment depends on the stage of the cancer. It may include some combination of surgery, radiation therapy, chemotherapy, or immunotherapy. Surgical options may include transurethral resection, partial or complete removal of the bladder, or urinary diversion.

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Where is the highest rate of bladder cancer?

In 2018, the highest rate of bladder cancer occurred in Southern and Western Europe followed by North America with rates of 15, 13, and 12 cases per 100,000 people. The highest rates of bladder cancer deaths were seen in Northern Africa and Western Asia followed by Southern Europe.

Is blood in urine a sign of bladder cancer?

Blood in the urine is the most common symptom in bladder cancer, and is painless. Visible blood in the urine may be of only short duration, and a urine test may be required to confirm non-visible blood. Between 80 and 90% of people with bladder cancer initially presented with visible blood.

Does smoking cigarettes cause bladder cancer?

Smoking (cigar, pipe, Egyptian waterpipe and smokeless tobacco) in any form increases the risk for bladder cancer. Quitting smoking reduces the risk. Risk of bladder cancer decreases by 30% within 1–4 years and continues to decrease by 60% at 25 years after smoking cessation.

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Does opium cause bladder cancer?

Opium consumption increases the risk of bladder cancer by 3-fold and concurrent use of opium and smoking increases the risk of bladder cancer by 5 times compared to the general population. Thirty percent of bladder tumors probably result from occupational exposure in the workplace to carcinogens.

Does eating vegetables help with bladder cancer?

As of 2019, there is limited high level evidence to suggest that eating vegetable and fruits decreases the risk of bladder cancer. A 2008 study concluded that “specific fruit and vegetables may act to reduce the risk of bladder cancer.” Fruit and yellow-orange vegetables, particularly carrots and those containing selenium, are probably associated with a moderately reduced risk of bladder cancer. Citrus fruits and cruciferous vegetables were also identified as having a possibly protective effect. However an analysis of 47,909 men in the Health Professionals Follow-Up Study showed little relation between cancer reduction and high consumption of fruits and vegetables overall, or yellow or green leafy vegetables specifically, compared to the reduction seen among those men who consumed large amounts of cruciferous vegetables. An inverse relation between in-takes of flavonols and lignans ( diphenolic compounds found in whole grains, legumes, fruits and vegetables) and aggressive bladder cancer has also been described.

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